SSRIs and Breastfeeding: What the Research Really Says—and How to Support Your Mental Health Naturally

Postpartum depression and anxiety are incredibly common—affecting about 1 in 5 new moms (according to reported data) (12). Postpartum mood disorders can shape how you connect with your baby, show up for your relationships, and feel in your own body day to day. For some, treatment includes SSRIs (selective serotonin reuptake inhibitors), which are often life-changing. But if you’re breastfeeding, it’s natural to wonder: Is this safe for my baby? And even beyond meds, what else can I do to support my mental health right now?

In this article, we’ll dig into what the research actually says and explore ways to support your nervous system, with or without prescription medication.

Untreated postpartum depression and anxiety don’t just affect the parent—they can lead to poor bonding, lower breastfeeding duration, and developmental concerns in children. According to a 2011 review in the American Journal of Psychiatry, maternal depression during the postpartum period is associated with insecure infant attachment, language delays, and behavioral issues later in life (1).

That’s why timely treatment is crucial.

According to the NIH’s LactMed - several SSRIs are considered compatible with breastfeeding. The key is choosing medications with low milk transfer and low infant serum levels .

• Considered the first-line SSRI for breastfeeding parents.

• Infant serum levels are often undetectable, and adverse events are rare.

• Multiple studies show no impact on growth or development.

• Also low transfer into breast milk.

• Undetectable levels in infant blood in most cases.

• Not associated with adverse neurodevelopmental outcomes.

• Longer half-life, accumulates in both milk and infants.

• Some infants may be more sensitive (e.g., colic, sleep disturbance).

• Generally avoided as the first choice, especially for parents of premature or medically fragile infants.

• Moderate levels in milk.Infant monitoring recommended.

• Can be safe with proper guidance.

Studies consistently show that untreated maternal mood disorders are far riskier than the minimal medication exposure via breast milk. Long-term consequences of untreated PPD may include:

• Reduced breastfeeding duration

• Delayed cognitive and emotional development in children

• Increased risk of future maternal mental health disorders (6)

Whether you’re taking SSRIs, exploring therapy, or just starting your journey toward healing, nervous system regulation is key to emotional resilience and hormone harmony. These evidence-based nutrients can play a powerful role:

Magnesium is essential for neurotransmitter function and helps regulate cortisol, GABA, and serotonin pathways (13). During pregnancy and lactation, your body’s demand for magnesium increases—and many people are unknowingly deficient (14).

Benefits include:

• Reduced anxiety and irritability

• Improved sleep

• Muscle relaxation and stress buffering

This golden spice isn’t just culinary—it’s also a natural mood enhancer. Clinical trials have shown saffron to be as effective as conventional antidepressants in mild to moderate depression—without the common side effects (7).

One study comparing saffron to fluoxetine found similar efficacy in mood improvement over 6 weeks (with better tolerability).

An amino acid found in green tea, L-theanine promotes calm alertness by supporting alpha brain wave activity. It’s particularly helpful for postpartum parents managing (8):

• Racing thoughts

• Sleep disruption

• Overwhelm or sensory overload

Tapping is a gentle, self-administered acupressure technique where you use your fingers to tap on specific meridian points (similar to acupuncture points) while repeating affirmations or naming your feelings.

Tapping has been shown to reduce cortisol levels and calm the amygdala, the part of the brain that activates the stress response (9).

While tapping lightly on your collarbone or the side of your hand, say:

“Even though I feel overwhelmed right now, I’m doing my best, and I’m allowed to feel this way.”

Repeat a few rounds while breathing slowly and evenly.

You don’t need an hour-long class. A few minutes of restorative yoga or intentional breathwork can downregulate the sympathetic nervous system (fight-or-flight) and activate the parasympathetic (rest-and-digest). 

• Legs up the wall (Viparita Karani) – Reduces cortisol, eases swelling, and calms the heart rate

• Box breathing (4-4-4-4) – Inhale for 4, hold for 4, exhale for 4, hold for 4. Repeat.

• Lion’s breath – Big inhale, then exhale forcefully while sticking out your tongue. It’s silly and grounding, especially with toddlers around.

Affirmations aren't about toxic positivity. They help redirect negative thought spirals and offer your brain a new, more compassionate narrative.

Positive affirmations engage the brain’s reward systems and have been shown to reduce rumination and increase resilience.

• “This is hard, but I’m not doing it wrong.”

• “My baby doesn’t need perfect. Just a connected, supported me.”

• “This feeling won’t last forever. It’s safe to soften.”

Even a 10-minute walk outdoors can significantly lower blood pressure, reduce anxiety symptoms, and increase vitamin D levels—critical for mood regulation.

Sunlight exposure first thing in the morning supports healthy circadian rhythms, which in turn support serotonin and melatonin balance (10)

A splash of cold water on your face, a cool shower, or even holding an ice cube can activate the diving reflex , which slows your heart rate and signals safety to the brain.

This is a fast-track way to bring the nervous system out of a panic loop. It’s especially useful during sudden anxiety spikes or sensory overwhelm.

Isolation fuels postpartum depression. But talking to someone—especially someone who gets it—can relieve shame and offer hope.

• Online groups like Postpartum Support International

• In-person mom groups at hospitals, birth centers, or lactation clinics

• Talking to a friend while walking or baby-wearing

Choosing how to treat postpartum depression or anxiety is deeply personal. But what’s non-negotiable is that you deserve support . SSRIs are widely considered safe for many breastfeeding parents, especially when paired with close monitoring and expert guidance. And for those seeking complementary tools, calming nutrients like Magnesium, Saffron, and L-Theanine can provide an added layer of support.

You’re not alone—and help is not only safe, but healing for both you and your baby.

 Disclaimer: We always recommend consulting with your healthcare provider for personalized medical advice, especially when it comes to medications and breastfeeding. Every body is different, and your provider can help you make the best choice for you and your baby.

1. Treatment of postpartum depression: clinical, psychological and pharmacological options
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9. Church, D., Geronilla, L., & Dinter, I. (2009). Psychological symptom change in veterans after six sessions of Emotional Freedom Techniques (EFT): An observational study. International Journal of Healing and Caring, 9(1), 1–16.  https://www.researchgate.net/publication/237301791_Psychological_symptom_change_in_veterans_after_six_sessions_of_EFT_Emotional_Freedom_Techniques_An_observational_study

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